{"id":27,"date":"2020-09-15T20:58:33","date_gmt":"2020-09-15T20:58:33","guid":{"rendered":"https:\/\/www.renalphysiopathology.com\/?page_id=27"},"modified":"2023-06-05T22:05:22","modified_gmt":"2023-06-05T22:05:22","slug":"original-articles","status":"publish","type":"page","link":"https:\/\/www.renalphysiopathology.com\/publications\/original-articles\/","title":{"rendered":"Original Articles"},"content":{"rendered":"
Figueroa S.M., Bertocchio J., Nakamura T., El-Moghrabi S., Jaisser F. and Amador C.A. Pharmaceutics. 2023; 15(5):1373.<\/h4>\n
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Tacrolimus (Tac) is a calcineurin inhibitor commonly used as an immunosuppressor after solid organ transplantation. However, Tac may induce hypertension, nephrotoxicity, and an increase in aldosterone levels. The activation of the mineralocorticoid receptor (MR) is related to the proinflammatory status at the renal level. It modulates the vasoactive response as they are expressed on vascular smooth muscle cells…<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>
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Diabetes mellitus (DM) causes high glucose (HG) levels in the plasma and urine. The (pro)renin receptor (PRR) is a key regulator of renal Na+ handling. PRR is expressed in intercalated (IC) cells of the collecting duct (CD) and binds renin to promote angiotensin (Ang) II formation, thereby contributing to Na+ reabsorption. In DM, the Kreb\u2019s cycle is in a state of suppression in most tissues. However, …<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>
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Chronic kidney disease (CKD) is characterized by renal dysfunction, which is a common feature of other major diseases, such as hypertension and diabetes. Unilateral ureteral obstruction (UUO) has been used as a model of CKD in experimental animals and consists of total obstruction of one kidney ureter. The UUO decreases renal blood flow, which promotes the synthesis of renin in the juxtaglomerular apparatus…<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>
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\nAdaptive immunity is crucial in cardiovascular and renal inflammation\/fibrosis upon hyperactivation of mineralocorticoid receptor. We have previously demonstrated that dendritic cells can respond to mineralocorticoid receptor activation, and the neutrophil gelatinase-associated lipocalin (NGAL) in dendritic cells is highly increased during aldosterone (Aldo)\/mineralocorticoid receptor-dependent cardiovascular damage…<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>
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\nCalcineurin inhibitors such as cyclosporine A (CsA) are still commonly used after renal transplantation, despite CsA\u2013induced nephrotoxicity (CIN), which is partly related to vasoactive mechanisms. The mineralocorticoid receptor (MR) is now recognized as a key player in the control of vascular tone, and both endothelial cell- and vascular smooth muscle cell (SMC)-MR modulate the vasoactive responses to vasodilators and …<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>
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\nAdaptive immune response has been implicated in inflammation and fibrosis as a result of exposure to mineralocorticoids and a high-salt diet. We hypothesized that in mineralocorticoid-salt\u2013induced hypertension, activation of the mineralocorticoid receptor alters the T-helper 17 lymphocyte (Th17)\/regulatory T-lymphocyte\/interleukin-17 (IL-17) pathway, contributing to cardiac and renal damage. We studied the …<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>
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Activation of the mineralocorticoid receptor has been shown to be deleterious in cardiovascular diseases (CVDs). We have recently shown that lipocalin 2 (Lcn2), or neutrophil gelatinase\u2013associated lipocalin (NGAL), is a primary target of aldosterone\/mineralocorticoid receptor in the cardiovascular system. Lcn2 is a circulating protein, which binds matrix metalloproteinase 9 and modulates its stability. We hypothesized that Lcn2 could be a mediator of …<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>
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Immune system activation is involved in cardiovascular (CV) inflammation and fibrosis, following activation of the mineralocorticoid receptor (MR). We previously showed that Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a novel target of MR signaling in CV tissue and plays a critical role in aldosterone\/MR-dependent hypertension and fibrosis. We hypothesized that the production of NGAL by immune cells may play an important part in the …<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>
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Increasing evidence shows that antigen-presenting cells (APCs) are involved in the development of inflammation associated to hypertension. However, the potential role of APCs in the modulation of renal sodium transport has not been addressed. We hypothesized that APCs participate in renal sodium transport and, thus, development of high blood pressure in response to angiotensin II plus a high-salt diet. Using transgenic mice that allow the …<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>